SupplementMain effects in studiesEvidenceBenefits studied
CalciumBMD +4% / -23.5pp, PTH ↓, Ca absorption ↑Strong1 of 3
Vitamin D↑25OHD ↓PTH, ↑BMD ↓resorptionStrong1 of 3
PotassiumDiuresis/K+ shifts, BP↓,K+↓Strong2 of 3
CollagenResorption ↓45%, formation ↑23%, BMD ↑6–10%, resorption ↓Strong1 of 3
IronGrowth+iron markers, +0.5–1.7 g/dLStrong1 of 3
Vitamin B9Folate status↑, Hcy↓, Anemia/toxicity↓, Hb↑Strong1 of 3
Folic AcidFolate↑, Hcy↓, Hb/iron status↑Strong1 of 3
ZincGrowth + zinc intake, Growth +10%Strong2 of 3
MultivitaminB-vitamin status ↑, Homocysteine ↓Strong2 of 3
Vitamin B12B12 status + homocysteine, Anemia/toxicity reduction +MMAStrong2 of 3
AspartateUDCA/LOLA: ↓AST/ALT, Iron/hepatotoxicity: ↑AST/ALTStrong1 of 3
Vitamin KBone activation +ucOC↓, BMD +1–5%Strong2 of 3
Whey ProteinProtein/lean mass +IGF-1, Satiety, glucose, insulinStrong2 of 3
IodineIodine status, growth +, Goiter/anemia, thyroid shrinkageStrong2 of 3
Vitamin AVitamin A status + growth, Anemia/mortality −15%Strong1 of 3
CaseinProtein status: +albumin, Metabolic/BP: glucose, BPStrong2 of 3
RiboflavinAnemia/iron status +9 g/L, Homocysteine/metabolism −23.6%Strong2 of 3
Beta-CaroteneCarotenoid/vitamin A boost, +85.7%Strong1 of 3LysLysineGrowth↑ lysine +12%, Growth↓ deficiencyStrong2 of 3
SilicaBMD/markers +6.9%, Hypersensitivity/tubules ↓Strong2 of 3
Soy IsoflavonesSpine/hip BMD ↑, Resorption markers ↓Strong1 of 3
MagnesiumBone density/turnover +1.7%, Bone healing/stabilityStrong1 of 3CopCopperHb/iron status +, Copper status/retention +Strong3 of 3
AlanineAlanine oxidation +15%, Nitrogen balance improvedStrong1 of 3BPrBeef Proteiniron status + absorption, muscle protein + growthStrong1 of 3
BLiBeef LiverCopper/Se status ↑, Sulfur/Fe ↓ CuStrong1 of 3
ThiThiamineGrowth +459g, z-scores, Infection fewer/shorterStrong1 of 3
AlfAlfalfaMilk yield +10.8%, Intake/growth/digestibility ↑Moderate1 of 3
LMeL-MethionineMet boost; AA markers, Cys spares Met needModerate1 of 3
LPrL-ProlineCTX -37%; BMD +1.6%, ALP/Hydroxyproline ↓Moderate1 of 3
AvoAvocadoLipids/LDL ↓ -10%, Vascular/fatty acids ↑Moderate1 of 3
Vitamin B6B-vitamin status ↑, Homocysteine ↓ / ω-3 ↑Moderate1 of 3BWaBlack WalnutALA/PUFA ↑, Energy/PUFA targets ↑Moderate1 of 3
CreatineBone loss −3.5→−1.3%, Bone density/geometry +Moderate1 of 3
Fish oilResorption ↓15%, BMD/BMC ↑Moderate1 of 3IsoIsoleucineNitrogen balance +38.3, Plasma isoleucine + BCAAModerate1 of 3
LHiL-HistidineBP ↓ histidine, Histidine digestibility +7%Moderate2 of 3
SpiSpirulinaProtein synthesis +AA, Micronutrient/child growthModerate1 of 3
BGrBarley GrassFiber digestion +17%, Cholesterol/mood/glycemia lowerModerate1 of 3
ManManganeseSpine BMD: +1.48%, Bone Mn: dose-dependentModerate2 of 3
Red CloverSpine BMD +4.1%, Bone markers improvedModerate1 of 3ALiAlpha-Linolenic AcidBone resorption ↓15%, Bone resorption ↓17%Weak1 of 3
Black CohoshBone markers improved, +? bone turnoverWeak1 of 3ChiChia SeedsALA ↑ +24-337%, No weight/inflammation changeWeak1 of 3
ChlChlorellaCarotenoids ↑; lipids ↓, Vitamin D2 ↑; cholesterol ↓Weak1 of 3
ColColostrum↑ BMD, strength, ↓ resorption, healingWeak1 of 3
GBeGoji BerryBioavailability +23%, Plasma zeaxanthin +26%Weak1 of 3
KelKelpTSH ↑; T3 ↓, Cholesterol +7.2%Weak1 of 3
KudKudzuCTx -0.05, Bone markers estrogen-likeWeak1 of 3
LeucineVitamin D/PTH: +2% BMD, Leucine EAA: BMC preservedWeak1 of 3LupLupinCholesterol/LDL ↓ ~4%, Protein/Zn uptake ↑Weak1 of 3
AKeAlpha-KetoglutarateBone resorption −37%, Bone thickness +21%Weak1 of 3
BorBoronBone formation markers +49.7%, Bone events 3% vs 11%Weak1 of 3
ChiChitosanBone loss ↓1.1–1.35 mm, Bone density +273 HUWeak1 of 3
CLiConjugated Linoleic Acid↓ resorption, ↑ formation, IGF-1 changedWeak1 of 3
EBaEucommia BarkBMD↑; BGP↑, CRP↓Weak1 of 3
HMBBone density/strength +6-28%, Bone density + strengthWeak1 of 3JKnJapanese KnotweedIMT/plaque/hs-CRP ↓, ROS/TNF-α/IL-6/CRP ↓Weak1 of 3
JujJujubeOPN +53.29 day3, Bone healing improvedWeak1 of 3
LycLycopene↑TAC, ↓NTx, ↑lycopene, ↓oxidative stressWeak1 of 3
MolMolybdenumCopper absorption -82%, Copper status/toxicityWeak1 of 3
MorMoringaBMI +2.0; albumin +0.6, CD4 unchangedWeak1 of 3
PomPomegranateBone age/growth +, Hormones/organ volumes +Weak1 of 3
RJeRoyal JellyPreserved femoral BMD, P1NP unchangedWeak1 of 3
ShaShatavariMilk volume +72h, Fullness faster, satisfactionWeak1 of 3
WMuWhite Mulberry↑ bone formation markers, ↓ bone resorption markerWeak1 of 3
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