Supplements › Vitamin

Calcium

The main mineral of bones and teeth, from dairy, fortified foods and supplements. Most studied for bone density and fractures, with small effects in trials.

Strongest evidenceBone healthStrong, 962 studies
Median dose in studies900 mg a dayFrom 1,706 study groups
Daily need for adults1,000 to 1,200 mg a dayUS. In the EU, 950 mg from age 25.
Upper limit2,000 to 2,500 mg a dayUS: 2,500 mg up to age 50, then 2,000 mg. EU: 2,500 mg.
Ask a doctor or pharmacist first

Ask a doctor or pharmacist first if you:

  • take levothyroxine: calcium carbonate can lower its absorption, and the label says to keep them 4 hours apart[1]
  • take a quinolone antibiotic, such as ciprofloxacin, or dolutegravir: calcium can lower how much of the medicine gets into the blood[1]
  • take lithium: long-term use can cause high blood calcium, and calcium supplements could add to this[1]
  • have had kidney stones: in the largest trial, calcium with vitamin D raised the risk by 17%[2]
  • have kidney disease: trials suggest a higher cardiovascular risk with calcium supplements[3]
  • have high blood calcium, or cancer or an overactive parathyroid gland, which are its usual causes[1]
  • are pregnant and considering a high dose: a 2025 review found little to no effect on pre-eclampsia in large trials[4]

Overview

What is calcium?

Calcium is the most abundant mineral in the body, and 98% of it is stored in the bones.[1] The rest helps muscles, nerves, blood vessels and blood clotting.[1]

Milk, yogurt and cheese are rich sources. Some vegetables, canned fish with bones and fortified foods also provide it.[1] Supplements usually contain calcium carbonate or calcium citrate, and some antacids contain calcium carbonate.[1]

What is calcium used for?

Large reviews found small effects of supplements on bones, and other uses have mixed or limited evidence:

  • Fractures. A 2026 review of 69 trials found little to no effect of calcium, alone or with vitamin D, on fractures or falls.[5]
  • Bone density. In people over 50, calcium raised bone density by 0.7% to 1.8%. The authors judged this gain unlikely to lower fracture risk in a way that matters.[6]
  • Rickets with a low calcium diet. In Nigerian children with rickets, 1,000 mg a day for 24 weeks brought near-complete healing in 61%, against 19% with vitamin D alone.[7]
  • Pre-eclampsia. A 2025 Cochrane review found little to no effect in large trials.[4] The World Health Organization (WHO) still recommends 1.5 to 2.0 g a day in pregnancy where calcium intake is low.[8]
  • Blood pressure. In people with normal blood pressure, more calcium lowered it by about 1.4 mmHg.[9]
  • Premenstrual syndrome. In the largest trial, 1,200 mg a day cut premenstrual symptoms by 48%, against 30% with placebo.[10]
  • After thyroid surgery. In a trial of 106 patients, low blood calcium with symptoms occurred in 1.9% with routine calcium and in 33.9% without it.[11]

Other expected benefits have little support. Calcium may make little or no difference to body weight, on low-certainty evidence.[12] In 34,157 women after menopause, calcium with vitamin D did not change sleep disturbance.[13] A later analysis of a trial in 212 people with prediabetes found better sleep with calcium only in some subgroups.[14] The evidence on leg cramps in pregnancy is unclear.[15]

Not every study of a calcium compound tests a tablet. A 2-year trial in 6,000 children, for example, tested toothpaste with arginine, a calcium compound and fluoride.[16]

Is calcium safe?

Within the upper limit, most adults tolerate it, but some risks are still debated. In placebo-controlled trials reviewed by EFSA, the EU food safety authority, 2,500 mg a day from food and supplements together was tolerated without adverse effects.[17] The US upper limit is 2,500 mg a day up to age 50 and 2,000 mg from age 51.[1] The risks that are discussed most are:

  • Stomach problems. Gas, bloating and constipation are possible. Calcium carbonate appears to cause more of them than calcium citrate.[1]
  • Kidney stones. In the largest trial, 1,000 mg of calcium with vitamin D a day raised the risk by 17%.[2] A review in people with osteoporosis did not find a significant increase.[18]
  • Heart. Reviews disagree. One found 15% more cardiovascular disease in healthy women after menopause,[19] and another found no link with heart attack, stroke or death.[20]
  • Prostate cancer. Some cohort studies link high calcium intake with a higher risk, but not when the calcium comes from supplements.[1] EFSA found no established link.[17]
  • Lead. Dolomite, bone meal and natural carbonate products had more lead in the past than refined forms. The gap has closed considerably since 2000, but some products can still have too much.[21]
  • Medicines. Calcium lowers the absorption or blood level of levothyroxine, quinolone antibiotics and dolutegravir, and can add to the risk of high blood calcium with lithium.[1]

People who take a medicine every day, have had kidney stones, have kidney disease or have high blood calcium should ask a doctor or pharmacist first.[1][2][3]

How it works

Almost all calcium in the body (98%) sits in the bones. A small part in the blood and tissues helps muscles, nerves, blood vessels and clotting.[1]

  1. Gut absorption

    Calcium crosses the wall of the gut in two ways: active transport, which needs vitamin D, and passive diffusion, which takes a larger share as intake rises.[1] Adults absorb about 25% of the calcium in food. The share is about 45% at an intake of 200 mg a day and 15% above 2,000 mg a day.[1]

  2. Blood and tissues

    A small pool of free (ionized) calcium controls the narrowing and widening of blood vessels, muscle work, blood clotting, nerve signals and hormone release.[1] The body keeps the blood level steady, usually at 8.8 to 10.4 mg/dL.[1]

  3. Storage in bone

    Bones and teeth hold calcium as hydroxyapatite, a mineral made of calcium and phosphate.[1] An adult body contains about 1,200 g of calcium in women and 1,400 g in men.[1]

  4. Bone remodeling

    Bone is broken down and rebuilt all the time, which releases calcium and lays it down again. Teeth do not do this.[1] After menopause, less estrogen speeds up the breakdown, and women lose about 1% of their bone density a year on average.[1]

  5. Daily losses

    Calcium leaves the body in urine, and less estrogen after menopause raises this loss.[1] The skin loses about 40 mg a day.[22]

Questions about how it worksDoes calcium need vitamin D to work? ›

Explainers

Benefits and studies

Each row is one benefit. The square shows the grade and the number of studies. Open a row to see the most trusted studies.

StrongModerateWeakNo trials
BenefitMain effects in studiesStudiesPeople

Dose

Fracture trials in older adults gave 500 to 1,200 mg of calcium a day, often with vitamin D.[1] The US recommended amount for adults is 1,000 to 1,200 mg a day, and EFSA, the EU food safety authority, sets 950 mg from age 25.[1][22]

Usual dose

For bones, 500 to 1,200 mg a day with 400 to 800 IU of vitamin D.[1] For pre-eclampsia, the World Health Organization (WHO) recommends 1.5 to 2.0 g a day where intake is low, and two large trials compared 500 mg with 1,500 mg.[8][23] For premenstrual symptoms, the largest trial gave 1,200 mg a day.[10] For blood pressure, a clear effect appeared at 1,000 to 1,500 mg a day.[9]

Daily need

The US recommended amount is 700 mg a day at 1 to 3 years, 1,000 mg at 4 to 8 years and 1,300 mg at 9 to 18 years. For adults it is 1,000 mg, rising to 1,200 mg for women from age 51 and for men from age 71. In pregnancy and breastfeeding it is the same as for other women of the same age.[1] EFSA sets 450 mg at 1 to 3 years, 800 mg at 4 to 10 years, 1,150 mg at 11 to 17 years, 1,000 mg at 18 to 24 years and 950 mg from age 25.[22]

Form

Calcium carbonate is 40% calcium by weight and calcium citrate is 21%.[1] US labels list the amount of calcium itself (elemental calcium).[1] Calcium supplements commonly contain 500 or 600 mg, multivitamins 200 to 300 mg, and antacid tablets 270 to 400 mg.[1]

When to take

With food: absorption of calcium supplements is greater with a meal. Calcium citrate can also be taken without food.[1] Absorption is highest at 500 mg or less at one time.[1] Levothyroxine, quinolone antibiotics and dolutegravir need a gap of some hours.[1]

How long

Fracture trials lasted 1 to 7 years.[1] Bone density rose in the first year and did not keep rising after that.[6] In the largest premenstrual trial, symptoms were lower by the second cycle.[10]

Upper limit

The US upper limit is 2,500 mg a day for adults up to age 50 and 2,000 mg from age 51, and 3,000 mg at 9 to 18 years.[1] EFSA sets 2,500 mg a day for adults, including in pregnancy and breastfeeding, from food and supplements together.[17] People who take a medicine every day should ask a doctor or pharmacist first.[1]

Doses in studies

Most studies gave 500 to 1,000 mg a day, for More than a year.

The counts are study groups. A study group is one set of people in a study who took the same dose. One study can have several groups. These are amounts from studies, not advice for you.

How much a day1,706 groups in 985 studies
  1. Up to 250 mg74 groups
  2. 250 to 500 mg462 groups
  3. 500 to 1,000 mg751 groups
  4. 1,000 to 2,500 mg357 groups
  5. 2,500 mg or more62 groups
For how long1,634 groups in 933 studies
  1. 1 week or less141 groups
  2. 1 to 4 weeks78 groups
  3. 1 to 3 months282 groups
  4. 3 to 6 months265 groups
  5. 6 to 12 months418 groups
  6. More than a year450 groups
Half of the groups took less than 900 mg a day. Half took more.Half of the groups took 500 to 1,000 mg a day. A quarter took less, a quarter took more.1170 of 1706 groups took 500 mg a day or more. Do not copy a study dose without a doctor.

Taken together

945 of 1733 study groups took calcium with something else. This shows what studies gave together, not what works together.

  1. Vitamin D491 studies759
  2. Vitamin D316 studies30
  3. Vitamin K19 studies25
  4. Magnesium19 studies24
  5. Folic Acid15 studies21
  6. Electrolytes11 studies18
  7. Iron12 studies18
  8. Zinc14 studies18
  9. Vitamin B1213 studies14
  10. Soy Isoflavones10 studies13
Bars and numbers count study groups. A companion is shown only when at least 3 different studies gave it.

Protocols

What studies used when they gave calcium for one goal, or to a group of people.

Each protocol describes what studies used, for one goal or for one group of people. It is not advice for you: talk to a doctor before you start a supplement.

Questions

12 questions in 4 groups. Open one for the short answer; each has its own page with the full answer and sources.

Basics
Which foods contain calcium?

Milk, yogurt and cheese are rich sources. Dairy products and foods with added dairy give about 72% of the calcium people get in the US.[1] Calcium in one serving:

  • plain low-fat yogurt, 8 ounces (227 g): 415 mg[1]
  • part-skim mozzarella, 1.5 ounces (43 g): 333 mg[1]
  • canned sardines with bones, 3 ounces (85 g): 325 mg[1]
  • nonfat milk, 1 cup: 299 mg[1]
  • soy milk with added calcium, 1 cup: 299 mg[1]
  • firm tofu made with calcium sulfate, half a cup: 253 mg[1]
  • cooked kale, 1 cup: 94 mg[1]

The body absorbs about 30% of the calcium in dairy and fortified foods.[1] Spinach has 123 mg in half a cup, but only 5% is absorbed, because oxalic acid binds the calcium.[1] Broccoli, kale and cabbage have calcium that is absorbed about as well as from milk, but they have less per serving.[1]

Open the answer with sources ›
What happens if you do not get enough calcium?

Over years, too little calcium weakens bones and can lead to osteoporosis. It can also cause rickets in children and osteomalacia (soft bones) in children and adults, although vitamin D deficiency is the more common cause of these two.[1]

Women after menopause and people who avoid dairy, such as vegans and people with lactose intolerance or a milk allergy, are most likely to get too little.[1] In the US, 39% of people aged 4 and older get less than the estimated average requirement.[1]

A low level of calcium in the blood (hypocalcemia) usually has another cause. Examples are too little vitamin D or magnesium, a problem with parathyroid hormone, critical illness and some medicines.[1] Its most common symptoms are numbness around the mouth, tingling in the hands and feet, and muscle spasms.[1] A normal blood level does not prove a good intake, because the body keeps this level steady. A bone density scan shows calcium status over a lifetime.[1]

One trial tested supplements for rickets where the diet is very low in calcium. In 123 Nigerian children whose diets gave about 200 mg a day, 1,000 mg a day gave better healing than vitamin D alone.[7]

Open the answer with sources ›
Benefits
Do calcium supplements prevent fractures?

Probably not by much in most adults. A 2026 review of 69 trials with 153,902 people found little to no benefit from calcium, vitamin D or both on fractures and falls.[5] Evidence for people at high risk or in care homes is limited, and one trial of extra dairy foods in care homes found fewer fractures.[5][24]

Read the full answer ›
Does calcium lower the risk of pre-eclampsia?

The newest evidence says little or not at all. A 2025 Cochrane review found little to no difference in pre-eclampsia in large trials (risk ratio 0.92, 14,730 women).[4] Older reviews found a much larger effect, driven by small trials.[25] The World Health Organization (WHO) recommends 1.5 to 2.0 g a day where calcium intake is low.[8]

Read the full answer ›
Does calcium lower blood pressure?

Slightly. A 2022 Cochrane review of 18 trials with 3,140 people with normal blood pressure found 1.37 mmHg lower systolic and 1.45 mmHg lower diastolic pressure.[9] The effect was larger in people under 35: 1.86 and 2.50 mmHg.[9] At 1,000 to 1,500 mg a day it was 1.05 and 2.03 mmHg.[9]

None of these trials counted how many people developed high blood pressure or reported side effects.[9] The review does not cover people who already have high blood pressure.[9] One expert review adds that blood pressure was more than 5 mmHg higher than with placebo in the hours after a large calcium dose.[26]

The DASH diet, which adds calcium from low-fat dairy, lowered blood pressure by 5.5 and 3.0 mmHg. That diet also adds potassium and magnesium, so the share due to calcium is unknown.[1]

Open the answer with sources ›
Does calcium help with premenstrual syndrome?

It may, but most of the evidence has a risk of bias. In the largest trial of premenstrual symptoms, 466 women took 1,200 mg of calcium a day as carbonate or a placebo for 3 cycles. Symptoms fell by 48% with calcium and 30% with placebo.[10]

Smaller trials also found less low mood, water retention, pain and fatigue.[27][28] A pilot trial in 39 women found a much smaller effect of calcium than of fluoxetine, an antidepressant.[29] A 2025 review of 31 trials of nutrition and PMS found consistent benefits on mood symptoms with calcium, but only 1 of the 31 had a low risk of bias.[30]

For period pain, one trial in 85 students gave 1,000 mg a day from the middle of the cycle until the pain ended. Pain was 1.6 points lower than with placebo on a 10-point scale. Blood loss did not change.[31]

Open the answer with sources ›
Does calcium help you lose weight?

Not in a way that matters. A 2024 Cochrane review of 18 trials found little to no difference in body weight in people with overweight or obesity (0.15 kg less, low certainty).[12] It found that calcium probably gives small drops in body mass index (0.18 kg/m²) and waist size (0.51 cm).[12]

A 2016 review of 33 studies with 4,733 people also found no difference overall (0.01 kg). It found small losses in some subgroups, such as children and people with a normal body mass index.[32] Another review of 41 trials found no effect of supplements on weight or body fat.[1]

Open the answer with sources ›
Safety
Do calcium supplements raise the risk of heart attacks?

This is not settled. A 2021 review of 13 double-blind trials found about 15% more cardiovascular disease in healthy women after menopause.[19] A 2023 review of 12 trials found no link with heart attack, stroke or death.[20] Calcium from food does not appear to raise the risk.[26]

Read the full answer ›
Do calcium supplements cause kidney stones?

They may raise the risk slightly, and the evidence is mixed. In the largest trial, 36,282 women took 1,000 mg of calcium with 400 IU of vitamin D or a placebo for 7 years, and kidney stones were 17% more common with the supplement.[2] The US upper limit is based on this finding.[1]

A 2022 evidence report for the US Preventive Services Task Force also found limited evidence of a higher risk.[33] Other reviews did not. A review of 10 studies in more than 8,000 people with osteoporosis found no significant increase.[18] A review of 11 trials in 51,419 adults found no link,[1] and a 2012 opinion of EFSA, the EU food safety authority, found no established link.[17]

A diet low in calcium did not protect better. A trial in 120 men with repeated calcium oxalate stones and high urine calcium compared two diets. One had normal calcium with less animal protein and salt, and the other was low in calcium. Over 5 years, 12 men on the first diet and 23 on the second had new stones.[34]

People who have had kidney stones should ask a doctor or pharmacist before they take calcium supplements.[2]

Open the answer with sources ›
Which medicines interact with calcium?

The main ones are these, according to NIH:

  • Levothyroxine (thyroid hormone). Calcium carbonate can lower its absorption. The label says to keep the two 4 hours apart.[1]
  • Quinolone antibiotics, such as ciprofloxacin. Calcium lowers their absorption. Taking the antibiotic 2 hours before or 2 hours after calcium prevents this.[1]
  • Dolutegravir (HIV medicine). Calcium can lower its blood level a lot. The label says to take it 2 hours before or 6 hours after calcium.[1]
  • Lithium. Long-term use can cause high blood calcium, and calcium supplements could add to this risk.[1]

Some medicines, such as bisphosphonates, cisplatin and proton pump inhibitors, can lower blood calcium.[1]

Calcium also affects iron. In a review of human studies, more calcium lowered short-term iron absorption by about 5.6%. Ferritin, a marker of iron stores, was lower at higher calcium intakes, but hemoglobin did not fall.[35] People who take a medicine every day should ask a doctor or pharmacist about calcium.[1]

Open the answer with sources ›
Forms and timing
Is calcium citrate better than calcium carbonate?

Neither is clearly better for most people. Carbonate has about twice as much calcium by weight, and two studies, one of them with a light breakfast, found it as well absorbed as citrate.[1][36][37] Citrate did better in other studies, can be taken without food and appears to cause fewer stomach problems.[38][39][1]

Read the full answer ›
Should calcium be taken with food?

Usually yes. Absorption of calcium supplements is greater with food, even in people with low stomach acid.[1] Calcium carbonate in particular may be absorbed poorly without a meal in people with low stomach acid. Calcium citrate can be taken without food.[1]

Taking the supplement with meals can also ease gas, bloating and constipation.[1] Oxalic acid in foods such as spinach and phytic acid in other plants bind calcium, and caffeine and phosphorus lower its absorption a little.[1]

Open the answer with sources ›

References

  1. Calcium: Fact Sheet for Health Professionals. NIH Office of Dietary Supplements. ods.od.nih.gov
  2. Calcium plus vitamin D supplementation and the risk of fractures. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. N Engl J Med, 2006. PMID 16481635
  3. Cardiovascular effects of calcium supplementation. Reid IR, Bolland MJ, Avenell A, Grey A Osteoporos Int, 2011. PMID 21409434
  4. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cluver CA, Rohwer C, Rohwer AC Cochrane Database Syst Rev, 2025. PMID 41330480
  5. Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis. Massé O, Mercurio CM, Dupuis S, Al Sahwi M, Arruda A, Dallaire G, et al. BMJ, 2026. PMID 42161415
  6. Calcium intake and bone mineral density: systematic review and meta-analysis. Tai V, Leung W, Grey A, Reid IR, Bolland MJ BMJ, 2015. PMID 26420598

Review history

  1. 4 Nov 2026CheckedReviewerChecked every claim against its source.
  2. 4 Nov 2026Page createdResearcherFirst edition, written from PubMed and public health sources.