SupplementMain effects in studiesEvidenceBenefits studied
FiberHbA1c ↓, 0.5%, Postmeal glucose ↓Strong1 of 1
Inositol↓ HOMA-IR, glucose, ↓ HbA1c, FPGStrong1 of 1
MagnesiumLower glucose, better sensitivity, Higher glucose, worse sensitivityStrong1 of 1ChrChromiumBlood sugar ↓, Insulin sensitivity ↑Strong1 of 1
PotassiumK↓, glucose↓, insulin sensitivity↑, glucose↓Strong1 of 1
AlanineAlanine↓ glucose↓, Alanine↑ glucose↑Strong1 of 1BerBerberineLower glucose/HbA1c, Lower insulin resistanceStrong1 of 1
InulinLower glucose/HbA1c, Better insulin resistanceStrong1 of 1WMuWhite MulberryPost-meal glucose ↓, FPG/HbA1c ↓Strong1 of 1
ButyrateButyrate↑ glucose↓, AUC−36 mg/dLStrong1 of 1CinCinnamonLower fasting glucose, HbA1c -0.83%Strong1 of 1
L-CarnitineLower glucose/insulin, Restored flexibilityStrong1 of 1
CarnitineLower glucose, HOMA‑IR, + glucose disposalStrong1 of 1ResResveratrolLower glucose, HOMA-IR, −0.5 mmol/L FPGModerate1 of 1
AntAnthocyaninsGlucose↓ insulin↓, HbA1c↓ FPG↓Moderate1 of 1
GinsengPPG ↓ 18-39%, Insulin sens ↑; HbA1c ↓Moderate1 of 1
Leucine↑ insulin, ↓ glucose, ↓ insulin resistanceModerate1 of 1
TurmericLower glucose/HbA1c, Improve insulin resistanceModerate1 of 1ChlChlorogenic AcidLower fasting glucose −27%, Better post‑meal glucose, insulinModerate1 of 1
AMuAkkermansia muciniphilaA1c↓ glucose↓, Akkermansia↑ endotoxin↓Moderate1 of 1
PsyPsylliumPostmeal glucose ↓14-31%, Fasting glucose/HbA1c ↓Moderate1 of 1
PipPiperineFasting glucose ↓ ~9-12, HbA1c ↓ ~0.3-0.8%Moderate1 of 1
ThiThiamine↓ fasting/2h glucose, ↔/↑ thiamine statusModerate1 of 1
BGrBarley GrassLower post-meal glucose, ↓ glucose/insulin peaksModerate1 of 1
EGaEpigallocatechin GallateGlucose ↓; insulin ↓1.43, Postmeal glucose ↓; insulin ↑Moderate1 of 1
SReSalacia ReticulataPost-meal glucose ↓, HbA1c/FBS ↓Moderate1 of 1
BMeBitter MelonLower fasting glucose, HbA1c -1.15%Moderate1 of 1
FlaFlaxseed OilInsulin ↓, HOMA-IR ↓, Glucose ↓11.8 mg/dLModerate1 of 1
NiacinEarly insulin +100%, Glucose iAUC -61%Moderate1 of 1
Vitamin B6Blood sugar ↓, HbA1c/FPG ↓Moderate1 of 1BerBergamotLower blood sugar, ~ modest decreaseModerate1 of 1
CLiConjugated Linoleic AcidGlucose/insulin ↓, +27% ISIModerate1 of 1
Garlic↓ Blood sugar, ↓ Blood sugar -3.1%Moderate1 of 1AvoAvocado↓ glucose spikes, ↓ insulin responseModerate1 of 1
CopCoptisLower blood sugar, HbA1c -0.75%Moderate1 of 1
CreatineGlucose↓, HOMA↓, HbA1c−1.1%Moderate1 of 1FenFenugreek↓ FPG, HbA1c, ↓ PPG, GIModerate1 of 1
IsoIsoleucine↓ glucose AUC, ↑ insulin/GLP-1Moderate1 of 1
MThMilk ThistleLower FPG/HbA1c (~20%, ~12%), Lower FBS, insulin doseModerate1 of 1
PPrPea ProteinGlucose ↓57%, Glucose ↓37%Moderate1 of 1
PBaPine Bark ExtractGlucose control −24 mg/dL, HbA1c −0.8%Moderate1 of 1
AstAstragalusBlood sugar ↓, Blood sugar ↓ +1.25Moderate1 of 1
BilBilberry↓ post-meal glucose, ↓ fasting/HbA1c glucoseModerate1 of 1
HesHesperidin↓ FPG/HbA1c, ↓ HOMA-IR / MGModerate1 of 1
QueQuercetinPostmeal glucose ↓, Insulin timing ↑Moderate1 of 1
SulSulforaphane↓ insulin resistance, ↓ fasting glucose −0.2 mmol/LModerate1 of 1
WKiWhite Kidney BeanBlood sugar: GI −34%, Blood sugar: post‑meal glucose −16%Moderate1 of 1
AllAlluloseGlucose ↓; insulin ↓, -8% post-meal glucoseWeak1 of 1
GluGlucomannanHbA1c, glucose ↓, Postmeal glucose/insulin ↓Weak1 of 1
TauTaurineLower fasting glucose, HbA1c, Lower insulin resistance ~30%Weak1 of 1
YacYaconLower fasting glucose, Lower post-meal insulinWeak1 of 1
ArtArtichoke ExtractLower fasting glucose, HOMA (-11.7%), Lower HbA1c, insulin resistanceWeak1 of 1
BenBenfotiamineLess sugar damage, ↓AGEs; −2.45 CRPWeak1 of 1
ChiChitosanLower post-meal glucose, ~10 mg/dL AUC↓Weak1 of 1
DihDihydromyricetinLower fasting glucose, Improved insulin resistanceWeak1 of 1
EryErythritolNo glucose rise, -lower postmeal glucoseWeak1 of 1
FucFucoxanthin↓ HOMA-IR, ALT, ↓ HOMA-IR, insulinWeak1 of 1
GOrGamma OryzanolFasting glucose ↓; HbA1c −0.7%, Metabolic markers ↓; LDL ↓Weak1 of 1
GSyGymnema SylvestreGlucose -1.3 mmol/L, HbA1c -0.4%Weak1 of 1
MyrMyricetinFasting glucose -27%, Postprandial glucose -20%Weak1 of 1
NetNettleFasting/post-meal sugar, HbA1c ↓, FBG −27 mg/dL, HbA1c −1.49%Weak1 of 1
OLeOlive Leaf ExtractInsulin sensitivity +15%, Glucose, insulin AUC ↓Weak1 of 1
ABlAgaricus Blazei↓ insulin resistance (HOMA-IR), ↑ adiponectin (+20%)Weak1 of 1
AmlAmlaLower fasting glucose, Lower post-load glucoseWeak1 of 1
BioBiotinTriglycerides/VLDL ↓, Carboxylase markers ↑Weak1 of 1
CapsaicinPost-meal glucose↓, Insulin AUC↓Weak1 of 1CelCelery SeedFBS -10.57 mg/dL, Lower blood sugarWeak1 of 1
ChiChia SeedsLower post-meal glucose, HbA1c -0.27%Weak1 of 1
ChiChicory RootButyrate +17.4%, Insulin sensitivity ↑Weak1 of 1
CFoColeus Forskohlii↓ insulin, −36.5%, ↓ HOMA-IR, −0.8Weak1 of 1
FisFisetinAsprosin↓, MCP-1↓, Adiponectin↑, stronger with trainingWeak1 of 1
JiaJiaogulanGlucose ↓ HbA1c −2.0, HOMA-IR ↓; BMI ↓Weak1 of 1
KudKudzuBMI, visceral fat ↓, Subcutaneous fat no changeWeak1 of 1
SchSchisandraLower fasting/postprandial glucose, −LDL, −insulin AUCWeak1 of 1
VanVanadiumLower glucose; better insulin sensitivity, ↓ glucose AUCWeak1 of 1
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