SupplementMain effects in studiesEvidenceBenefits studied
GABAAnxiety↓ stress†, Sleep/attention↓ anxietyStrong1 of 1
LavenderAnxiety↓ cortisol↓, Sleep/stress↓ 5-10Strong1 of 1
MelatoninAnxiety, cortisol ↓, Sleep, stress ↓Strong1 of 1
TryptophanAnxiety ↑; Trp ↓, Stress hormones ↑; mood ↓Strong1 of 1SJoSt. John's WortDepression ↓, anxiety ↓, Anxiety/somatic ↓Strong1 of 1
LBaLemon Balm↓ Anxiety/Stress, ↓4‑herb, −1.19 dStrong1 of 1
ChamomileAnxiety ↓ 5.2, Depression/stress ↓Strong1 of 1
TheanineAnxiety, sAA ↓, BP stress response ↓Moderate1 of 1
AshwagandhaStress/anxiety ↓ PSS, Anxiety ↓ HAM-A −41%Moderate1 of 1SafSaffronStress/anxiety ↓ p<0.04, Depression/anxiety ↓ p<0.001Moderate1 of 1
ValerianStress/anxiety ↓, Sleep ↑, anxiety ↓Moderate1 of 1GlyGlycineAnxiety/stress −2.4, Depression/suicideModerate1 of 1
PFlPassion FlowerAnxiety ↓; cortisol ns, Sleep time +23 minModerate1 of 1
Rhodiola RoseaAnxiety/stress ↓, Stress markers ↓Moderate1 of 1BMoBacopa MonnieriStress/anxiety ↓, HR ↓, Cortisol ↓, mood ↑Moderate1 of 1
GinsengStress/anxiety ↓ PSS, VAS-A, Cortisol↓ HRV↑, anxiety↓Moderate1 of 1HopHopsAnxiety/stress ↓, Sleep/time ↑Moderate1 of 1
CSaClary SagePain relief −2.5, Lower BP, breathingModerate1 of 1
PhoPhosphatidylserineCortisol/stress ↓, Mood/fatigue ↓Moderate1 of 1
EleEleutheroBurnout/anxiety ↓, Stress response ↓Weak1 of 1
SkuSkullcapAnxiety ↓; mood/sleep ↑, Anxiety ↓; sleep ↑Weak1 of 1
ApiApigeninMigraine symptoms down, Menopausal psychological -3.74Weak1 of 1
BSkBaikal SkullcapAnxiety −2.07; sleep +27m, Depression/anxiety improved modestlyWeak1 of 1
HawHawthornAnxiety↓ −5%, Stress markers↓Weak1 of 1
JujJujubeSleep/mood ↓ stress, Stress score -5.8Weak1 of 1
Black CohoshLess stress, lower anxiety, Improved symptoms, less bleedingWeak1 of 1CelCelery SeedAnxiety/depression ↓ -6.78/-3.63, Blood pressure ↓Weak1 of 1
CMoCnidium MonnieriMood/anxiety −51%, Blues −16.4%Weak1 of 1
DClDevil's ClawLower pain, stiffness, Higher pain thresholdWeak1 of 1
InositolPanic/OCD symptoms reduced, Mood/anxiety improvedWeak1 of 1JiaJiaogulanTrait anxiety ↓16.8%, Total anxiety ↓17.8%Weak1 of 1
Lion's ManeStress ↓ −9.5, Speed ↑ 6.7%Weak1 of 1MBaMagnolia BarkInsomnia, anxiety, mood improved, No % reportedWeak1 of 1
NeeNeemPain ↓ 2.9–4.9, No inflammation changeWeak1 of 1
OrnOrnithine↓ cortisol/DHEA-S, better sleep, ↓ anger-hostilityWeak1 of 1
Panax GinsengStress hormones ↓, HRV/feelings improvedWeak1 of 1RosRosemaryAnxiety down significantly, Pre-op anxiety -P=0.001Weak1 of 1
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