SupplementMain effects in studiesEvidenceBenefits studied
IodineTSH↑,Tg↓, Goiter↓,volume↓44%Strong1 of 2
Soy IsoflavonesHot flashes/symptoms −40–61%, Estrogen metabolism +31% ratioStrong1 of 2
InositolInsulin↓ testosterone↓ ovulation↑, Pregnancy/egg quality↑ hormones↓Strong1 of 2
SeleniumThyroid antibodies -36%, TSH/FT4 shiftsStrong1 of 2
Black CohoshSymptom relief; hormones unchanged, Hot flashes −85%Strong2 of 2
GinsengErectile function +7, Desire/satisfaction +6Strong1 of 2
MagnesiumPTH/cortisol balance, Insulin/inflammation balanceStrong1 of 2
ZincIGF-1/growth ↑, +48%, +20%Strong1 of 2
ArginineED scores +5-12, Fertility/pregnancy +47%Moderate1 of 2
Panax GinsengErectile function +7, Sperm quality +85%Moderate1 of 2
AshwagandhaThyroid + T3/T4, Stress/cortisol ↓Moderate2 of 2
Red CloverHot flushes, symptoms, +73.5% / -75.4%Moderate1 of 2
Aspartate↑ LH/FSH, +5.4, ↑ Testosterone/IGF-1, +0.8Moderate1 of 2TTeTribulus TerrestrisErection +5.4, Desire/testosterone +192%Moderate2 of 2
KudKudzuMenopause relief; FSH/LH stable, Vaginal estrogenic effects; VMI +172%Moderate1 of 2
FenFenugreekHormones ↑, symptoms↓, PCOS shift, cysts↓Moderate2 of 2
Arachidonic AcidAA/Oxylipins ↑; PTB risk, Hormones/stress: cortisol ↓Moderate1 of 2BerBerberineAndrogen↓, SHBG↑, Insulin resistance↓Moderate1 of 2
FlaFlaxseed OilPhytoestrogens +160%, Androgen/insulin ↓Moderate1 of 2
LMeL-MethionineImmune ↓; TgAb −, Inflammation ↓; Steroidogenesis ↑Moderate1 of 2
FenFennelBleeding +54 pp, Hormone symptoms improvedModerate1 of 2
I3Indole-3-CarbinolEstrogen metabolism shift, +4.55 ratioModerate1 of 2
HopHopsHot flashes/symptoms −23.4, Hormone profiles no changeModerate1 of 2
SafSaffronErectile function +77%, Female sexual functionModerate1 of 2
SagSageAndrogen down, ovulation up, Insulin resistance downModerate1 of 2
ALiAlpha-Linolenic AcidLeptin -4.70 ng/mL, Insulin/testosterone downModerate1 of 2
BWaBlack WalnutLipids + HbA1c
LDL -6%, HbA1c -0.2%, Glucose/insulin control
Insulin response +26%Moderate1 of 2
EllEllagic AcidCortisol↓, BDNH↑, AMH↓, LDL↓Moderate1 of 2
EPrEvening Primrose OilHot flashes/sweating ↓, Irritability, CRP ↓Moderate1 of 2
LicLicoriceBP↑; renin/aldo↓, Insulin/PRL↓; cycles+Moderate1 of 2
RJeRoyal JellyAndrogen ratios +0.05, PMS score -11.75Moderate1 of 2
SJoSt. John's WortHot flashes, −50%, Mood/menopause, −42%Moderate1 of 2
DamDamianaMenopause symptoms -, Embryo quality +22%Weak2 of 2
SPaSaw PalmettoUrinary symptoms, +1.9 mL/s, Erectile function, +3.2 IIEF-5Weak2 of 2
PPrPea ProteinInsulin↑; glucagon↑, Glucose↓; insulin↑Weak1 of 2
PMiPueraria MirificaMGCS ↓20-33, E2/FSH/LH slight↓Weak1 of 2
BlaBlack Seed Oil↓ leptin, IL-6, sperm quality improvedWeak1 of 2
ChrChrysinAndrogens/estrogen ↑, +342%Weak1 of 2
CitCitrullineSemen quality, e‑NOS, Erectile function, sexual wellnessWeak1 of 2
DIMDIMEstrogen shift +47%, Endoxifen ↓, SHBG ↑Weak1 of 2
DQuDong QuaiHot flushes, sleep 73%, Night sweats 69%Weak1 of 2
FucFucoxanthinHormone balance: insulin↓ HOMA-IR↓, Hormone balance: ALT↓ CAP↓Weak1 of 2
KelKelpTSH↑, T3↓, Iodine↑, TSH↑Weak1 of 2
AlanineHormone balance +alanine, Glucose/IGF-I shiftsWeak1 of 2BorBoronLess cramps, duration, Lower pain severityWeak1 of 2
BSuButea SuperbaErections +82.4%, Blood tests unchangedWeak1 of 2
ChlChlorophyllGLP-1 up, −5kg, LDL/total cholesterol downWeak1 of 2
CorCordycepsMotility/morphology up, DFI downWeak1 of 2
DAsD-Aspartic AcidTestosterone +16%, Sperm motility +43%Weak1 of 2
ForForskolinFat loss, free T +17%, Higher free testosteroneWeak1 of 2
Ginkgo BilobaVPA +0.5 mV, FSFI no changeWeak1 of 2MacMacaLibido/sexual desire +, Erectile/sexual function +1.6Weak1 of 2
MMuMaitake MushroomOvulation ↑ 77%, Cycle ovulation ↓ 42%Weak1 of 2
PhytosterolsSymptom score −13.7, Vasomotor worse, LDLWeak1 of 2PumPumpkin Seed OilHormone symptoms ↓4.9, BP/HDL shiftWeak1 of 2
SchSchisandraMenopause symptoms ↓, Hot flushes/palpitations ↓Weak1 of 2
ShaShatavariHormones + symptoms, Breast/lactation supportWeak1 of 2
TAlTongkat AliErection + testosterone up, Combined group: greatest gainWeak1 of 2
WYaWild YamGreene score -12mo, Hormone profile improvedWeak1 of 2
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