SupplementMain effects in studiesEvidenceBenefits studied
IronHb/ferritin ↑, Anemia ↓ 47%Strong1 of 3
IodineTSH↑,Tg↓, Goiter↓,volume↓44%Strong2 of 3
Fish oilMood swings, EPA/DHA +, Strength, function +Strong1 of 3
Soy IsoflavonesHot flashes/symptoms −40–61%, Estrogen metabolism +31% ratioStrong1 of 3
CarnitineFatigue/QoL ↑, Muscle/survival ↑Strong1 of 3
InositolInsulin↓ testosterone↓ ovulation↑, Pregnancy/egg quality↑ hormones↓Strong1 of 3
SeleniumThyroid antibodies -36%, TSH/FT4 shiftsStrong1 of 3
Vitamin CEnergy, mood +vitality, Mood, fatigue +18Strong1 of 3
Black CohoshSymptom relief; hormones unchanged, Hot flashes −85%Strong2 of 3
Acetyl-L-CarnitineCognition/mood +, Pain/fatigue/function +Strong1 of 3
GinsengErectile function +7, Desire/satisfaction +6Strong1 of 3
MagnesiumPTH/cortisol balance, Insulin/inflammation balanceStrong1 of 3
Alpha-Lipoic AcidVitality: pain/function/QoL, Vitality: antioxidants/metabolicStrong1 of 3
Vitamin AHb/retinol ↑, Anemia ↓Strong1 of 3
Beta-CaroteneVitamin A, anemia, memory, Maternal mortality −49%Strong1 of 3
ZincIGF-1/growth ↑, +48%, +20%Strong1 of 3
Panax GinsengErectile function +7, Sperm quality +85%Moderate2 of 3
ArginineED scores +5-12, Fertility/pregnancy +47%Moderate1 of 3
AshwagandhaThyroid + T3/T4, Stress/cortisol ↓Moderate2 of 3
CollagenBone/metabolic ↑, Strength/healing ↑Moderate1 of 3
Red CloverHot flushes, symptoms, +73.5% / -75.4%Moderate1 of 3
CurcuminBrain/mood + memory, +0.5 ESModerate1 of 3
Aspartate↑ LH/FSH, +5.4, ↑ Testosterone/IGF-1, +0.8Moderate1 of 3TTeTribulus TerrestrisErection +5.4, Desire/testosterone +192%Moderate3 of 3
Vitamin B6Liver enzymes/fatty liver -42%, B6/PLP, performance/weightModerate1 of 3IsoIsoleucineBCAAs, growth, BCAAs, survivalModerate1 of 3
KudKudzuMenopause relief; FSH/LH stable, Vaginal estrogenic effects; VMI +172%Moderate1 of 3
SagSageAndrogen down, ovulation up, Insulin resistance downModerate2 of 3
ThiThiamineFatigue/endurance ↑, +26% enduranceModerate1 of 3
BGlBeta-GlucansGlucose/appetite↓, Infections/survival↑Moderate1 of 3
CitCitrullineHeart function +20%, TB recovery +weight gainModerate2 of 3
FenFenugreekHormones ↑, symptoms↓, PCOS shift, cysts↓Moderate2 of 3
SpiSpirulinaMetabolic health: −1.43% HbA1c, Weight/lipid gains: −41 mg/dL TCModerate1 of 3
Arachidonic AcidAA/Oxylipins ↑; PTB risk, Hormones/stress: cortisol ↓Moderate1 of 3BerBerberineAndrogen↓, SHBG↑, Insulin resistance↓Moderate1 of 3
DanDanshenVitality +20.9, Fatigue ↓Moderate1 of 3
FlaFlaxseed OilPhytoestrogens +160%, Androgen/insulin ↓Moderate1 of 3
LMeL-MethionineImmune ↓; TgAb −, Inflammation ↓; Steroidogenesis ↑Moderate1 of 3
NADNADHFatigue, +responder, Recovery, +3-4 daysModerate1 of 3
Rhodiola RoseaFatigue/attention ↑, +VO2max, recoveryModerate1 of 3
AlanineAlanine ↓/↑ energy, Performance/fatigue +20%Moderate2 of 3CorCordycepsKidney protection, fewer infections, Fat loss, muscle gainModerate2 of 3
FenFennelBleeding +54 pp, Hormone symptoms improvedModerate1 of 3
GTeGreen Tea ExtractEnergy use/fat burn +3%, Vitality/health improvedModerate1 of 3
I3Indole-3-CarbinolEstrogen metabolism shift, +4.55 ratioModerate1 of 3
PolPolicosanolCardiovascular recovery +87.5%, Lipids/claudication betterModerate1 of 3
AstAstaxanthinAntioxidant + fertility, +pregnancy, -ROSModerate1 of 3
BWaBlack WalnutLipids + HbA1c
LDL -6%, HbA1c -0.2%, Glucose/insulin control
Insulin response +26%Moderate2 of 3
EllEllagic AcidCortisol↓, BDNH↑, AMH↓, LDL↓Moderate2 of 3
GlyGlycerolAmmonia/HE ↓, Performance/rehydration ↑Moderate1 of 3
HopHopsHot flashes/symptoms −23.4, Hormone profiles no changeModerate1 of 3
ReishiFatigue/QoL +38.7%, Fitness/vitality boostModerate1 of 3SafSaffronErectile function +77%, Female sexual functionModerate1 of 3
ALiAlpha-Linolenic AcidLeptin -4.70 ng/mL, Insulin/testosterone downModerate1 of 3
CocCocoa ExtractTestosterone/strength +20–48%, Sexual function +73–122%Moderate1 of 3
ECaEcklonia CavaBody fat↓, cholesterol↓, Post-meal glucose↓Moderate1 of 3
EPrEvening Primrose OilHot flashes/sweating ↓, Irritability, CRP ↓Moderate1 of 3
HawHawthornExercise +38.9s, Symptoms/QoL improvedModerate1 of 3
LicLicoriceBP↑; renin/aldo↓, Insulin/PRL↓; cycles+Moderate2 of 3
RJeRoyal JellyAndrogen ratios +0.05, PMS score -11.75Moderate1 of 3
AMeS-Adenosyl MethionineHomocysteine/SAM balance, Liver outcomes & survivalModerate1 of 3
SJoSt. John's WortHot flashes, −50%, Mood/menopause, −42%Moderate1 of 3
TArTerminalia ArjunaPump function +LVEF, Fatigue/lipids/BP ↓Moderate1 of 3
UAUrolithin AEndurance +VO2max, +5–10%, Strength/biomarkers +12%; CRP downModerate1 of 3
DamDamianaMenopause symptoms -, Embryo quality +22%Weak2 of 3
SPaSaw PalmettoUrinary symptoms, +1.9 mL/s, Erectile function, +3.2 IIEF-5Weak2 of 3
ChlChlorogenic AcidEnergy/mood + alertness, Frontal oxygenation / fatigueWeak1 of 3
PPrPea ProteinInsulin↑; glucagon↑, Glucose↓; insulin↑Weak1 of 3
PMiPueraria MirificaMGCS ↓20-33, E2/FSH/LH slight↓Weak1 of 3
BLiBeef LiverHigher Se, gene shifts, Less vitamins, fatter carcassesWeak1 of 3
BCuBlack CurrantEndurance +23%; +8%, Vascular +1.1%Weak1 of 3
BlaBlack Seed Oil↓ leptin, IL-6, sperm quality improvedWeak1 of 3
ChrChrysinAndrogens/estrogen ↑, +342%Weak1 of 3
DIMDIMEstrogen shift +47%, Endoxifen ↓, SHBG ↑Weak1 of 3
DQuDong QuaiHot flushes, sleep 73%, Night sweats 69%Weak1 of 3
FucFucoxanthinHormone balance: insulin↓ HOMA-IR↓, Hormone balance: ALT↓ CAP↓Weak1 of 3
GamGambogeAntioxidants +18%, Inflammation markers downWeak1 of 3
GBeGoji Berry+testosterone, sperm quality, +energy, sleep, GI regularityWeak1 of 3
IdeIdebenoneCognition + sustained, Respiration +6.27%pWeak1 of 3
KelKelpTSH↑, T3↓, Iodine↑, TSH↑Weak1 of 3
ProPropolisHbA1c −1%; insulin/IR, Energy intake/QoL improvedWeak1 of 3
UbiquinolHeart function +7-8%, Inflammation/blood counts improvedWeak1 of 3WYaWild YamMuscle size/quality ↑, HbA1c ↓Weak2 of 3
BVeBee VenomPain +1.1; function +3.1, VAS improved; 82% vs 62%Weak1 of 3
BSiBeta-SitosterolWeight gain +2.8 kg, Lymphocytes up; no culture changeWeak1 of 3
BGiBlack GingerPain/function ↑; QoL ↑, Week 4–8Weak1 of 3
BluBlueberry ExtractMemory +0.055, BP -7 mmHgWeak1 of 3
BorBoronLess cramps, duration, Lower pain severityWeak1 of 3
BSuButea SuperbaErections +82.4%, Blood tests unchangedWeak1 of 3
ChlChlorophyllGLP-1 up, −5kg, LDL/total cholesterol downWeak1 of 3
DAsD-Aspartic AcidTestosterone +16%, Sperm motility +43%Weak1 of 3
EchEchinaceaProperdin +21%, Vitality scores improvedWeak1 of 3
ForForskolinFat loss, free T +17%, Higher free testosteroneWeak1 of 3
Ginkgo BilobaVPA +0.5 mV, FSFI no changeWeak1 of 3GlyGlyNACGSH restored, oxidative stress↓, Mitochondria improvedWeak1 of 3
JujJujubeFatigue ↓, Sleep/mood ↑Weak1 of 3
MacMacaLibido/sexual desire +, Erectile/sexual function +1.6Weak2 of 3
MMuMaitake MushroomOvulation ↑ 77%, Cycle ovulation ↓ 42%Weak1 of 3
MPrMucuna PruriensMotor benefit; +50%, Longer ON; +70 minWeak1 of 3
NiacinRecurrent MI ↓, 15-year mortality ↓14%Weak1 of 3OStOat Straw+ADFI, +G:F, ↓E. coliWeak1 of 3
PanPantothenic AcidB-vitamins up; appetite +weight, Convalescent strength +appetiteWeak1 of 3
PhytosterolsSymptom score −13.7, Vasomotor worse, LDLWeak1 of 3PumPumpkin Seed OilHormone symptoms ↓4.9, BP/HDL shiftWeak1 of 3
RibRiboseVitality/health +, EF/BNP/bioenergetics +Weak1 of 3
RosRosemaryEpigenetic age ↓3.14y, Methyl-adaptogens ↑; MF +8.1Weak1 of 3
SchSchisandraMenopause symptoms ↓, Hot flushes/palpitations ↓Weak1 of 3
SesSesaminFatigue recovery, -PCOOH, LDL antioxidant resistanceWeak1 of 3
ShaShatavariHormones + symptoms, Breast/lactation supportWeak1 of 3
SGiSiberian GinsengDesire,satisfaction ↑, Total function no changeWeak1 of 3
TAlTongkat AliErection + testosterone up, Combined group: greatest gainWeak1 of 3
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