SupplementMain effects in studiesEvidenceBenefits studied
CollagenHealing rate +56%, Scar control +32ppStrong4 of 9
Vitamin DPsoriasis control; +70% PASI, Vitiligo repigmentation; +35%Strong1 of 9
Vitamin ASkin clearer, less acne, Wrinkles/pigment improved, irritation lowerStrong3 of 9
IodineInfection↓; PI -13%, Healing↑; 3 daysStrong2 of 9
ZincBarrier/healing +7pp, Acne/dermatitis reducedStrong3 of 9
ProbioticsEczema ↓, barrier↑, Hydration/texture↑, redness↓Strong1 of 9
ArgininePerfusion+healing, Infections↓,stay↓Strong1 of 9
SilicaMTA: repair +95%, Ca-silicate: bridge/healingStrong5 of 9
Vitamin CPigment/brightening +1.3, Wound/scar healing improvedStrong4 of 9
Aloe VeraPain+healing +76.6%, Erythema/itching -14%Strong3 of 9
Vitamin EPhotoprotection, antioxidant, Wound healing, scarsStrong5 of 9
NiacinBarrier +25%/−20%, Flushing −50%Strong1 of 9
IronSkin-darkening ↓, Pigmentation ↓Strong2 of 9GlyGlycerolHydration + barrier, TEWL↓, moisture↑Strong1 of 9
ChiChitosanRepair/healing +fast, Bleeding control -90%Strong2 of 9
Fish oilAcne inflammation ↓, Wound healing ↑Strong2 of 9TTrTea Tree OilSoothing symptoms, mites, Acne/inflammation, +38%Strong7 of 9
LysLysineWound healing +34%, Bleeding/pain controlStrong3 of 9
Essential Amino AcidsDryness/hydration ↓, Wrinkles/brightness ↑Strong2 of 9BorBoronSeverity↓, clearance↑, Itch↓, flares↓Strong2 of 9
CapsaicinPain/itch ↓, Redness/burning ↓Strong1 of 9
PrebioticsEczema severity −18, Allergy incidence −57%Strong1 of 9
GlutathioneAntioxidants↑, acne?, Lipid peroxidation↓Strong2 of 9ZeaZeaxanthinEye/retina: MPOD +15%, Skin carotenoids: +42%Strong1 of 9
PanPantothenic AcidBarrier repair + hydration, Pain/redness reduction + faster healingModerate4 of 9
GKoGotu KolaRedness/barrier −38%, Scar/wound scores↓Moderate2 of 9
Beta-CaroteneAntioxidant photoprotection + skin redness, Carotenoids/pigmentation +10-67%Moderate2 of 9
Arachidonic Acid↓ platelet activation, ↑ repair markersModerate2 of 9CopCopperInfection↓ healing↑, TE +0.63 ICUModerate2 of 9
ProPropolisFaster wound closure, Less inflammationModerate3 of 9
CurcuminRedness/irritation ↓, Lesions/ulcers ↓Moderate1 of 9FumFumaric AcidPsoriasis improvement, GI/flushing side effectsModerate3 of 9
SeleniumWound healing +50%, Skin inflammation +functionModerate2 of 9GlyGlycineSkin hydration/elasticity, +26%, +5.7Moderate1 of 9
LPrL-ProlineCollagen synthesis +55%, Wound healing fasterModerate3 of 9
PBaPine Bark ExtractElasticity/texture +9%, Pigment/spot reductionModerate2 of 9
Sodium BicarbonateLess injection pain, Burning pain ↓Moderate3 of 9
TurmericWound healing +60%, Pruritus/psoriasis improvedModerate1 of 9GTeGreen Tea ExtractAcne/infection less, +64%, Wrinkles/density improvedModerate1 of 9
N-Acetyl CysteineSkin healing improved, Inflammation/oxidation reducedModerate1 of 9CalCalendulaLess dermatitis, pain, Faster healing, less painModerate3 of 9
ChamomileSoothing: ↓inflam, faster heal, Soothing: −25% phlebitisModerate2 of 9GraGrape Seed ExtractBarrier/moisture +1, Pigment/texture/wrinkles +Moderate2 of 9
Inositol↓ insulin, androgens, + acne score improvementModerate3 of 9LicLicoriceRedness/itching ↓; 2%, Hydration/barrier ↑; inflammation ↓Moderate1 of 9
PomPomegranateHydration/elasticity +brightness, Sunburn resistance +34.7Moderate1 of 9
QueQuercetinHealing + elasticity, Acne + barrierModerate1 of 9
Whey ProteinAcne: lesions -38.6%, Psoriasis/Eczema: improved scoresModerate1 of 9
BromelainFaster debridement, less surgery, Pain ↓, repair ↑Moderate1 of 9EllEllagic AcidCollagen +37-41%, Pigment/lightening improvementModerate1 of 9
LycLycopenePigment/carotenoid↑, UV redness↓Moderate2 of 9
MagnesiumSkin aging/redness ↓, Eczema/psoriasis barrier ↑Moderate1 of 9MHoManuka HoneyFaster healing, +11%, Less infection, better repairModerate1 of 9
PhenylalanineLightening/depigmenting skin, +10–13%,−18–21%Moderate1 of 9
AlanineMucositis ↓14/20, Severity/duration ↓Moderate2 of 9AmlAmlaLightening, comparable, Hydration+elasticity +26%Moderate3 of 9
AntAnthocyaninsWrinkles −10.6%, Moisture upModerate1 of 9
BBaBirch BarkFaster closure, +1 day, Less dysplasia, 64%Moderate2 of 9
ButyrateHealed ulcers +78%, Lighter skin +13%Moderate1 of 9CarCarnosineSmoother skin roughness, Less dryness +89%Moderate1 of 9
Coenzyme Q10Wrinkles/density +16.1%, Psoriasis/aging severityModerate1 of 9EGaEpigallocatechin GallateInflammation/lesions ↓; −22% RID, Pigmentation/scar repair ↑Moderate1 of 9
GarlicFungal cure +2%, Microcirculation +22%Moderate1 of 9
LuteinSkin carotenoids ↑, Sunnier, less red skinModerate2 of 9
PhytosterolsLess itch, pain, Faster healing, more clearanceModerate1 of 9SpeSpermidineHair growth ↑, AK lesions −24%Moderate1 of 9
Vitamin B12Better skin severity, Less itching/painModerate1 of 9AChActivated CharcoalHealing +20%, Bacterial load -23%Moderate1 of 9
AKeAlpha-KetoglutarateFast graft closure +31d, Less protein breakdownModerate2 of 9
Alpha-Lipoic AcidRepigmentation/healing +90%, Photoageing/roughness -50.8%Moderate1 of 9AstAstaxanthinWrinkles/elasticity/hydration improved, UV resistance +5 mJ/cm2Moderate2 of 9
BGlBeta-GlucansImmune/recurrence: improved, Hydration/repair: +68.2%Moderate1 of 9
DanDanshenScar healing +91.4%, Flap ischemia/necrosis ↓Moderate1 of 9
EPrEvening Primrose OilHydration up, TEWL down, +8.9 CORN unitsModerate3 of 9
LHiL-HistidineRepair ↑ nitrogen +130, Histidine/UV protection improvedModerate1 of 9
LecLecithinBarrier/pigment ↓, Inflammation/pain ↓Moderate1 of 9
MThMilk ThistleLess dermatitis/mucositis, Better wound healingModerate1 of 9
SPaSaw PalmettoHair counts +25/cm2, Improvement ~60%Moderate3 of 9
Soy IsoflavonesWrinkles ↓, +10%, Hydration/pigment improvedModerate1 of 9LacLactoferrinInflammatory lesions -39%, Total lesions -23%Moderate1 of 9
LeucineProtein balance + synthesis, Wound repair + collagenModerate1 of 9MyrMyrrhPain↓, healing↑, REEDA↑, sensitivity↓Moderate2 of 9
PapPapainSkin reactions -10, Mucositis/skin reactions -10Moderate1 of 9
PepPeppermint OilItch −36, soothing, Pressure injury −54%, soothingModerate1 of 9
PhoPhosphatidylcholine↓Hydration, ↑TEWL, -Moderate1 of 9
Vitamin B6PPE/HFS ↓ incidence, QoL/pain improvedModerate1 of 9
Vitamin KBruising severity -20%, Rash severity womenModerate2 of 9WMuWhite MulberryVascularity/pigment ↓, MASI −1.2Moderate1 of 9
YarYarrowAnti-inflammatory soothing, Pain/swelling reliefModerate2 of 9
BioBiotinHair shedding↓, Hoof growth +15%Weak5 of 9
RJeRoyal JellyUlcers, oxidative stress, Mucositis healing timeWeak2 of 9
AOfAlthaea OfficinalisDry mouth, QoL, VVC symptoms, betterWeak3 of 9
CasCastor OilHydration via tear retention, Tear stability +25%Weak2 of 9
ChlChlorogenic AcidHydration↑, TEWL↓, Pigment/erythema↓Weak1 of 9
LMeL-MethionineFaster healing, fewer relapses, Lesion scores downWeak2 of 9
ManMangosteenSmoother texture, +1 mm³, Less acne, better toleranceWeak2 of 9
NeeNeemLice cure 100%, +68% less viableWeak4 of 9
ResResveratrolHydration, TEWL, Wound closure, TNFWeak1 of 9
RosRosemaryHair growth + itching, Antioxidant scalp protectionWeak2 of 9
RutinIrritation/redness ↓, Wrinkles/elasticity ↑Weak1 of 9
ArtemisininAcne severity ↓, Itch relief 82%Weak1 of 9AvoAvocadoFirmness/elasticity improved, No hydration changeWeak1 of 9
BerBerberinePain/inflammation ↓, Ulcers healed fasterWeak1 of 9
BetBetaineLess irritation, no acne change, AE −4.2 pp, no acneWeak1 of 9
BlaBlack Seed OilPain relief, healing faster, Burning/lesions ↓ ~90%Weak2 of 9
BorBorage OilHydration ↑, TEWL ↓ ~10%, Acne lesions ↓Weak3 of 9
ChiChicory RootBarrier, texture improved, Radiodermatitis delayedWeak1 of 9
ChrChromiumHair: hirsutism -1.8, Nails: noneWeak1 of 9
CilCilantroRedness ↓; tinea signs ↓, UV erythema, fungal infectionWeak1 of 9
FenFenugreekAnti-aging mood, antioxidant, Blood pressure and memoryWeak1 of 9
GingerItch −55%; eczema, Wrinkles/pigment/redness −20–30%Weak1 of 9HibHibiscusHydration +1.6, TEWL -0.7, Redness, moisture increaseWeak1 of 9
JujJujubeHyperpigmentation ↓0.56, Acne lesions ↓Weak1 of 9
LarLarchLesions, +56% responders, Discomfort, +21% healedWeak1 of 9
MultivitaminTexture: no change, Pigment: ↓ melaninWeak1 of 9OLeOlive Leaf ExtractFaster healing, -0.8 days, Less pain, itchingWeak1 of 9
PipPiperineVitiligo repigmentation + irritation, Hair regrowth, SALT ↓Weak1 of 9
RiboflavinAcne improvement +2.6%, Less pain, fewer side effectsWeak1 of 9SagSageHealing & pain: ~6.7d, Redness/inflammation: reducedWeak1 of 9
SBuSea BuckthornHealing rate +33%, Healing time shorterWeak2 of 9
ShiShilajitCollagen synthesis +94-165%, Microperfusion, collagen genesWeak1 of 9
SpiSpirulinaMelanosis/keratosis improved; hair As -47.1%, Lesions and burning improvedWeak1 of 9
UrsUrsolic AcidBrightening: MI −10.2%, Hydration/elasticity: R2 +28%Weak1 of 9
WHaWitch HazelErythema -20-27%, Barrier+appearance +34%Weak2 of 9
ALiAlpha-Linolenic AcidHydration ↑, TEWL ↓, Dryness/itch ↓, meds ↓Weak1 of 9
ArnArnicaLess bruising, Reduced swellingWeak2 of 9
AstAstragalusUlcers, +2.03%, Hand-foot syndrome, +26%Weak1 of 9
BVeBee VenomAcne fewer lesions, Bacteria down, acne clearedWeak2 of 9
BLiBeef LiverRetinol, D3 ↓, Backfat, marbling ↑Weak1 of 9
BSiBeta-SitosterolDermatitis unchanged, Itch/pain ↓11%Weak1 of 9
BilBilberryWrinkles −10.6%; smoother skin, Elasticity +12.4%; antioxidant +20.8%Weak1 of 9
BCuBlack CurrantLess redness, −13.83, Softer skin, hydrationWeak1 of 9
BPeBlack PepperRepigmentation + significant, Burning, redness + piperineWeak1 of 9
BluBlueberry ExtractAesthetic, elasticity, thickness, Elasticity +9.36%, thickness +8.42%Weak1 of 9
BosBoswelliaRoughness/fine lines/elasticity, -Weak1 of 9
CClCat's ClawStomatitis severity down; similar to miconazole, Candida counts downWeak1 of 9
ChlChlorophyllLesions, sebum down, Clearance +67%Weak1 of 9
CinCinnamonLess pain, better healing, -1.6 REEDAWeak1 of 9
CloCloveHealing +48%, Pressure loweredWeak1 of 9
ColColostrumSkin/subcutaneous fat +5.5%, Limb size +2.3%Weak1 of 9
CopCoptisAcne severity ↓, Metabolic markers ↓Weak1 of 9
DanDandelionSwelling ↓, +73% mouth opening, Pain unchangedWeak1 of 9
DMADMAEFirmness up, Shear-wave +Weak1 of 9
DodDodder SeedMoisture, elasticity ↑, Itching ↓Weak1 of 9
DBlDragon's BloodHealing +10%, Pain reducedWeak1 of 9
EchEchinaceaElasticity+collagen, MDA↓, Barrier lipids+eczema↓Weak2 of 9
FlaFlaxseed OilHydration +46 µS, TEWL -10%/50%Weak1 of 9
FTiFo-TiMelanin ↑36.9%, TYR/α-MSH ↑Weak2 of 9
ForForskolinLess cellulite, thinner waist, +NR circumference, +thicker epidermisWeak1 of 9
GamGambogeSmoothness/texture +1.0, Acne/inflammation ↓Weak1 of 9
GinsengWrinkle reduction; collagen↑, Eye wrinkles, roughness↓Weak1 of 9GCoGreen Coffee ExtractHydration, barrier, blood flow, + hydration, - TEWLWeak1 of 9
HChHorse ChestnutLess slough, fewer changes, Healing unchangedWeak1 of 9
JasJasmineCollagen/elastin + aging, Hydration/elasticity, non‑irritantWeak1 of 9
JiaJiaogulanHair density +14/cm², Hair elasticity/diameter +58 gfWeak1 of 9
KaeKaempferolMoisture/elasticity ↑, Itch ↓Weak1 of 9
Krill OilBarrier, hydration, elasticity, TEWL -1.23; hydration +3.66Weak1 of 9ManManganeseLaser downtime/erythema ↓, Mucositis 1.5d vs 19dWeak2 of 9
MonMonolaurinLess staph, lower severity, ~95% fewer staphWeak1 of 9
MSMMSMRedness,papules,h hydration, Itching improvedWeak1 of 9
MulMulleinWound healing: -1.59, Healed by day10: +54.7%Weak2 of 9
NonNoniLeishmaniasis lesions: ~80% improved, Parasite activity: in vitroWeak1 of 9
OreOregano OilCure +57%, Recurrence -100%Weak1 of 9
PumPumpkin Seed OilVellus hairs -6.7, Regrowth hairs +0.77Weak1 of 9
RHiRose HipWrinkles -3.74, Moisture, elasticity upWeak1 of 9
SchSchisandraHydration ↑17.35, TEWL ↓4.41, Redness ↓54.61Weak1 of 9
SerSerrapeptaseSwelling, pain reduction, Mouth opening +4.8mmWeak1 of 9
SkuSkullcapCure↑ 94.74%, Relapse↓ 16.00%Weak1 of 9
TArTerminalia ArjunaKOH negativity, itch, non-inferior vs terbinafineWeak1 of 9
Vitamin B9Hemoglobin ↑, Memory/attention ↑Weak1 of 9WBaWillow BarkLess redness, no irritation, Reduced inflammation, dermatitis scoresWeak1 of 9
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