Hyaluronic acid

Who should avoid hyaluronic acid supplements?

Updated 9 Nov 2026

Short answer

EFSA judged rooster comb extract, a source of hyaluronic acid, safe at the use its maker proposed, up to 80 mg a day. The maker's target group was the general population, except three groups: pregnant women, children and people who react to sodium hyaluronate or to bird protein.[1] People in the excluded groups should ask a doctor or pharmacist first.[1]

People who take medicines every day should also ask first, because some dietary supplements interact with prescription or non-prescription medicines.[2]

Sources (2)

  1. Scientific Opinion on Rooster Combs Extract. European Food Safety Authority, 2013. efsa.onlinelibrary.wiley.com
  2. Osteoarthritis: In Depth. National Center for Complementary and Integrative Health, 2016. www.nccih.nih.gov

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For education; not medical advice. Talk to a doctor before you start, stop or change a supplement.