Vitamin DDoes vitamin D interact with any medicines?
Updated 3 Nov 2026
Short answer
Yes, with a few. Thiazide diuretics together with vitamin D can raise blood calcium too high, mostly in older adults and people with kidney problems.[1] High doses of vitamin D may make atorvastatin, lovastatin and simvastatin work less well.[1]
Corticosteroids such as prednisone reduce calcium absorption and change how the body uses vitamin D. The weight-loss drug orlistat lowers vitamin D absorption.[1] If you take any of these, ask a doctor or pharmacist about your vitamin D intake.[1]
Sources (1)
- Vitamin D: Fact Sheet for Health Professionals. NIH Office of Dietary Supplements. ods.od.nih.gov
More about vitamin d
What is vitamin D?How do you get vitamin D from sunlight and food?What is vitamin D used for?What vitamin D blood level is too low?Is vitamin D safe?Does vitamin D prevent fractures?For education; not medical advice. Talk to a doctor before you start, stop or change a supplement.