Which medicines interact with zinc?

Zinc can interact with some antibiotics and with penicillamine, and some diuretics lower zinc levels:^[1]

• Quinolone antibiotics such as ciprofloxacin, and tetracycline antibiotics: zinc and the antibiotic can block each other's absorption. Taking the antibiotic at least 2 hours before or 4 to 6 hours after zinc reduces this effect.^[1]
• Penicillamine, used for rheumatoid arthritis and Wilson disease: zinc can lower its absorption and action. Taking them at least 1 hour apart reduces this effect.^[1]
• Thiazide diuretics such as chlorthalidone and hydrochlorothiazide: they raise the loss of zinc in urine and lower zinc in the blood.^[1]

Iron supplements of 25 mg or more taken at the same time can lower zinc absorption.^[1] People who take a medicine every day should discuss their zinc intake with a doctor or pharmacist.^[1]