ElectrolytesWhich medicines interact with electrolyte supplements?
Updated 9 Nov 2026
Short answer
ACE inhibitors, angiotensin receptor blockers and potassium-sparing diuretics such as spironolactone keep potassium in the body, so extra potassium can raise blood levels too high.[1] Loop and thiazide diuretics do the opposite: they increase the loss of potassium and magnesium in urine.[1][2] Magnesium lowers the absorption of tetracycline and quinolone antibiotics: take these at least 2 hours before or 4 to 6 hours after it. Keep magnesium and bisphosphonates at least 2 hours apart.[2]
Sources (2)
- Potassium: Fact Sheet for Health Professionals. NIH Office of Dietary Supplements. ods.od.nih.gov
- Magnesium: Fact Sheet for Health Professionals. NIH Office of Dietary Supplements. ods.od.nih.gov
More about electrolytes
What are electrolytes?Do you need electrolyte drinks every day?What are electrolytes used for?What are the signs of low electrolytes?Are electrolyte supplements safe?Do electrolytes help with dehydration from diarrhea?For education; not medical advice. Talk to a doctor before you start, stop or change a supplement.