GlutathioneDoes glutathione help Parkinson's disease?
Updated 10 Nov 2026
Short answer
Trials so far found no clear benefit. A 2026 review covered 9 studies of NAC and glutathione with 196 people. Glutathione given through the nose raised brain levels only a little and did not significantly improve symptoms.[1] In a 3-month trial in 45 people, 100 or 200 mg through the nose 3 times a day was no better than placebo. All groups improved, including the placebo group.[2] In a 4-week pilot trial in 21 people, glutathione into a vein did not change symptom scores more than placebo.[3]
In the same 2026 review, NAC improved symptoms, but the authors called the evidence for both early.[1]
Sources (3)
- The role of N-acetylcysteine and glutathione in the management of Parkinson's disease: a systematic review of oxidative biomarkers and clinical outcomes. Mohammed I, Nankya Y, Hong UT, Kan A, Abdelhafid AM, Latunde-Dada GO Amino Acids, 2026. PMID 41874704
- Phase IIb Study of Intranasal Glutathione in Parkinson's Disease. Mischley LK, Lau RC, Shankland EG, Wilbur TK, Padowski JM J Parkinsons Dis, 2017. PMID 28436395
- Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease. Hauser RA, Lyons KE, McClain T, Carter S, Perlmutter D Mov Disord, 2009. PMID 19230029
More about glutathione
What is glutathione?Is glutathione absorbed when taken by mouth?Does glutathione work?Do glutathione levels fall with age?Is glutathione safe?Does glutathione lighten skin?For education; not medical advice. Talk to a doctor before you start, stop or change a supplement.